Microparticle Production of Active Pharmaceutical Ingredient Using Supercritical Antisolvent Process: A Case Study of Allopurinol

Allopurinol is a relatively water-insoluble drug and, consequently, its efficacy was frequently limited by the dissolution or solubility phenomena. The purpose of this study to improve solid-state properties and behavior allopurinol via supercritical antisolvent (SAS) process using CO2 as an antisolvent. effects operating parameters: temperature (35–55 °C), pressure (80–100 bar), solution concentration (8–15 mg/mL), flow rate (2–4 L/min), (0.25–0.50 mL/min) were studied. Moreover, physical unprocessed SAS-processed analyzed SEM, FTIR, DSC, TGA, PXRD. also investigated compared. In case study, effectively micronized from 15.3 μm 1.35 at optimal condition. results verify that can be controlled improved micronization SAS technology.